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In the SURMOUNT-3 trial, individuals who received tirzepatide after a comprehensive 12-week lifestyle intervention achieved a mean 25 % weight reduction, compared to 4.8 % in the placebo group [170], suggesting a benefit for staged lifestyle intervention with GLP-1s
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Bdnf and exercise enhance neuronal DNA repair by stimulating creb-mediated production of apurinic/apyrimidinic endonuclease 1
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